This is a good question. Those folks who are technical analysts ignore all of that. They could care less. However, those of us, myself included, who are fundamental analysts do place some significance on these numbers. Only problem is that they are all based on what happened last year, not what is going to happen next year. Darn.
What I do is try to determine how a company relates to others in the same industry. That involves comparing sales, market cap, P/E, growth rate, ROA, D/E, dividends, book value, to that of like companies. I ignore ROE completely. To me it is ROA that is more important. Some folks fixate on margins. Other folks fixate on what analysts predict.
But what we really should be fixating on is what is likely to happen in the future. 2 years down the road, 3 years down the road, and 5 years down the road. Then plan your strategy based on that. At the moment things are looking pretty gloomy.